Ammonium Chloride → (S)-1-(2-Bromophenyl)ethanamine

HRID 605338노트

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HRID 605338 반응식
[N:1]([C@H:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[Br:12])[CH3:5])=[N+]=[N-].[NH4+].[Cl-].[In]>CCO.O>[Br:12][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[C@@H:4]([NH2:1])[CH3:5]

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 5359967IndiumHCID 866155641-[(1S)-1-azidoethyl]-2-bromobenzene

생성물 1

HCID 2530257(S)-1-(2-Bromophenyl)ethanamine수율 88%

시약·촉매·용매 1

HCID 19096565Water ethanol용매

실험 절차

To a solution of (S)-1-(1-azidoethyl)-2-bromobenzene (45 mg, 0.2 mmol) in EtOH/H2O (5 mL/5 mL) was added in NH4Cl (108 mg, 2.0 mmol) and indium (91 mg, 0.8 mmol). The mixture was refluxed overnight. The reaction mixture was filtered, washed with EtOH and evaporated. The residue was triturated with AcOEt and filtered. The filtrate was evaporated to give the title compound (35 mg, 88%).

후처리

  1. temperatureThe mixture was refluxed overnight
  2. filtrationThe reaction mixture was filtered
  3. washwashed with EtOH
  4. customevaporated
  5. customThe residue was triturated with AcOEt
  6. filtrationfiltered
  7. customThe filtrate was evaporated

출처 및 근거

ORD 기록
ord-041214f9c7a8431296a83e4f76dac554
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910595B2

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