Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Phenylpropan-1-amine → (RS)-{4-[2-(7-Isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(1-phenyl-propylcarbamoyl)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Phenylpropan-1-amine | HCID 18054 | — |
| 반응물 | 4-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid | HCID 59376892 | — |
| 생성물 | (RS)-{4-[2-(7-Isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(1-phenyl-propylcarbamoyl)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester | HCID 67040479 | 90% |
반응 단계
According to the procedure in Example 385F, the title compound was prepared using 4-(4-tert-butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid (prepared in Example 385E) and (RS)-1-phenylpropylamine: yield 90%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07910595B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-79b55eb50d114e1285c27af2b4a92b32 |
| 출처 메모 | uspto-grants-2011_03 |