4-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-nitro-benzoic acid methyl ester → Methyl 3-amino-4-(4-(methoxycarbonylamino)phenylthio)benzoate

HRID 605402노트

반응식

HRID 605402 반응식
[CH3:1][O:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12][C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][C:14]=2[N+:23]([O-])=O)=[CH:8][CH:7]=1)=[O:4].COC(=O)C1C=CC(SC2C=CC(NC(OC(C)(C)C)=O)=CC=2)=C([N+]([O-])=O)C=1>>[NH2:23][C:14]1[CH:15]=[C:16]([CH:21]=[CH:22][C:13]=1[S:12][C:9]1[CH:10]=[CH:11][C:6]([NH:5][C:3]([O:2][CH3:1])=[O:4])=[CH:7][CH:8]=1)[C:17]([O:19][CH3:20])=[O:18]

참가 물질

3

반응물 2

HCID 593768704-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-nitro-benzoic acid methyl esterHCID 67041007Methyl 4-(4-(methoxycarbonylamino)phenylthio)-3-nitrobenzoate

생성물 1

HCID 67040749Methyl 3-amino-4-(4-(methoxycarbonylamino)phenylthio)benzoate수율 88%

실험 절차

The title compound was prepared by the procedure in Example 385C substituting the product from Example 441A for the product of Example 385B. The reaction was purified by silica gel chromatography (ethyl acetate/CHCl3=1/9) to give the title compound (yield 88%).

후처리

  1. customThe title compound was prepared by the procedure in Example 385C
  2. customThe reaction was purified by silica gel chromatography (ethyl acetate/CHCl3=1/9)

출처 및 근거

ORD 기록
ord-e156897df9164f93ad499a016bae9f56
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910595B2

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