(6-Methoxy-indan-1-ylidene)-acetic acid ethyl ester → Ethyl (6-methoxyindan-1-yl)acetate

HRID 605528

반응식

HRID 605528 반응식
[CH2:1]([O:3][C:4](=[O:17])[CH:5]=[C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[CH2:8][CH2:7]1)[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:17])[CH2:5][CH:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[CH2:8][CH2:7]1)[CH3:2]

참가 물질

4

반응물 1

HCID 67045796(6-Methoxy-indan-1-ylidene)-acetic acid ethyl ester

생성물 1

HCID 11064342Ethyl (6-methoxyindan-1-yl)acetate수율 94%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

(6-methoxy-indan-1-ylidene)-acetic acid ethyl ester (3.18 g, 14.5 mmol) was dissolved in MeOH (30 ml). A catalytic amount of 10% Pd/C was added and the reaction was stirred under an atmosphere of hydrogen (balloon) for 2 h. The reaction mixture was filtered through Celite to provide pure (6-methoxy-indan-1-yl)-acetic acid ethyl ester (2.98 g, 94%) as a clear oil. LCMS: 235.0 (M+1)+.

후처리

  1. filtrationThe reaction mixture was filtered through Celite

출처 및 근거

ORD 기록
ord-c7ea3d53359d473bb0b156cfbf7764a2
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915253B2

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