Potassium Iodide → 4-[(Ethylpropylamino)methyl]benzenemethanol

HRID 605579노트

반응식

HRID 605579 반응식
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][OH:10])=[CH:5][CH:4]=1.[CH2:11]([NH:13][CH2:14][CH2:15][CH3:16])[CH3:12].[I-].[K+].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[CH2:11]([N:13]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][OH:10])=[CH:5][CH:4]=1)[CH2:14][CH2:15][CH3:16])[CH3:12]

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 883981-Propanamine, N-ethyl-HCID 5107660[4-(Chloromethyl)phenyl]methanol

생성물 1

HCID 866357944-[(Ethylpropylamino)methyl]benzenemethanol수율 52.9%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 5 g of [4-(chloromethyl)phenyl]methanol, 5.56 g of N-ethylpropan-1-amine, 5.29 g of potassium iodide and 4.41 g of K2CO3 in 200 ml of acetonitrile is left to stir at AT for 48 hours. The reaction mixture is concentrated under vacuum, the residue is taken up with water, the mixture is extracted with DCM, the organic phase is dried over Na2SO4, and the solvent is evaporated off under vacuum. 3.5 g of the expected compound are obtained.

후처리

  1. waitis left
  2. concentrationThe reaction mixture is concentrated under vacuum
  3. extractionthe mixture is extracted with DCM
  4. dry with materialthe organic phase is dried over Na2SO4
  5. customthe solvent is evaporated off under vacuum

출처 및 근거

ORD 기록
ord-c40dd9c3b98f4a65bbec09837094493d
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915258B2

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