Methylamine → 4-Bromo-N-methylthiazole-2-carboxamide

HRID 605945노트

반응식

HRID 605945 반응식
C([O:3][C:4]([C:6]1[S:7][CH:8]=[C:9]([Br:11])[N:10]=1)=O)C.[CH3:12][NH2:13]>CO>[CH3:12][NH:13][C:4]([C:6]1[S:7][CH:8]=[C:9]([Br:11])[N:10]=1)=[O:3]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 49757955Ethyl 4-bromothiazole-2-carboxylate

생성물 1

HCID 575900864-Bromo-N-methylthiazole-2-carboxamide

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

4-Bromothiazole-2-carboxylic acid ethyl ester (500 mg, 2.13 mmol) is dissolved in methanol (1 mL) and methyl amine in methanol (10 mL) is added. The mixture is stirred overnight at room temperature. Evaporation of the solvent under reduced pressure affords the title compound as yellow solid. LCMS: Rt 0.92 min (100%) m/z (ESI) 219/221 (M+H)+.

후처리

  1. customEvaporation of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-1ac158033ba34f7089024cf60db846ad
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915256B2

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