Acetic Anhydride → (4-Bromopyridin-2-yl)methyl acetate

HRID 605957

반응식

HRID 605957 반응식
[Br:1][C:2]1[CH:7]=[CH:6][N+:5]([O-])=[C:4]([CH3:9])[CH:3]=1.[C:10]([O:13]C(=O)C)(=[O:12])[CH3:11]>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:9][O:13][C:10](=[O:12])[CH3:11])[CH:3]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 544461394-Bromo-2-methyl-1-oxo-1lambda~5~-pyridine

생성물 1

HCID 45789873(4-Bromopyridin-2-yl)methyl acetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-bromo-2-methylpyridine-1-oxide (4.00 g, 21.40 mmol) in DCM (20 mL) is added acetic anhydride (6 mL). The mixture is stirred at room temperature for 1 hour and then heated at reflux overnight. The solvent is removed under vacuum and the crude product is filtered through a silica plug, eluting with DCM to afford the title compound as an orange oil (815 mg).

후처리

  1. temperatureheated
  2. temperatureat reflux overnight
  3. customThe solvent is removed under vacuum
  4. filtrationthe crude product is filtered through a silica plug
  5. washeluting with DCM

출처 및 근거

ORD 기록
ord-38636f2731b94ebe82902bd00ee169fc
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915256B2

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