Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol hydrochloride → 4-(3,4-Difluorobenzyl)-4-hydroxypiperidine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol hydrochloride | HCID 21887872 | — |
| 반응물 | Tert-butyl 4-(3,4-difluorobenzyl)-4-hydroxypiperidine-1-carboxylate | HCID 86680862 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-(3,4-Difluorobenzyl)-4-hydroxypiperidine hydrochloride | HCID 86680863 | — |
반응 단계
To a solution of tert-butyl 4-(3,4-difluorobenzyl)-4-hydroxypiperidine-1-carboxylate (4.7 g) in ethanol (30 mL) was added 2.0 M HCl/ethanol solution (36 mL), and the mixture was stirred overnight at room temperature. The solvent was evaporated under reduced pressure, and the obtained solid was recrystallized from ethyl acetate/diisopropyl ether to give the title compound (3.5 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09440990B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-dc0cf333b11e4a979ca546b66958a5af |
| 출처 메모 | uspto-grants-2016_09 |