4-[2-(2-Fluorophenyl)ethyl]-3-methoxypyridine → HCID 22248091, 화합물

HRID 606199노트

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HRID 606199 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][C:11]=1[O:16][CH3:17]>C(#N)C.C(Br)C1C=CC=CC=1>[CH2:8]([N:13]1[CH2:14][CH2:15][C:10]([CH2:9][CH2:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])=[C:11]([O:16][CH3:17])[CH2:12]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:2]=1

참가 물질

4

반응물 1

HCID 222482284-[2-(2-Fluorophenyl)ethyl]-3-methoxypyridine

생성물 1

HCID 22248091HCID 22248091, 화합물수율 159.9%

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 7498Benzyl Bromide용매

반응 조건

온도
50 °C

실험 절차

After dissolving 1.12 g of 4-[2-(2-fluorophenyl)ethyl]-3-methoxypyridine in 10 ml of acetonitrile, 0.63 ml of benzyl bromide was added, the mixture was stirred for 2 hours at 50° C., and the solvent was distilled off under reduced pressure. The residue was dissolved in 20 ml of methanol, and then 552 mg of sodium borohydride was added while cooling on ice and the mixture was stirred for 1 hour. Water was added to the reaction solution, and extraction was performed with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and filtered with NH silica gel. The solvent was distilled off under reduced pressure to obtain the title compound (1.26 g, 80% yield).

후처리

  1. additionwas added
  2. distillationthe solvent was distilled off under reduced pressure
  3. dissolutionThe residue was dissolved in 20 ml of methanol
  4. addition552 mg of sodium borohydride was added
  5. temperaturewhile cooling on ice
  6. stirringthe mixture was stirred for 1 hour
  7. additionWater was added to the reaction solution, and extraction
  8. washThe organic layer was washed with saturated brine
  9. dry with materialdried over anhydrous magnesium sulfate
  10. filtrationfiltered with NH silica gel
  11. distillationThe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-9f6215eafa5a4f07aa68c3b89e101c86
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915274B2

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