Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol, 1,1-diethoxy-, 1-acetate → 6-Fluoro-[1,2,4]triazolo[4,3-a]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol, 1,1-diethoxy-, 1-acetate | HCID 84166 | — |
| 반응물 | 5-Fluoro-2-hydrazinylpyridine | HCID 19916786 | — |
| 용매 | Cyclohexane | HCID 8078 | — |
| 생성물 | 6-Fluoro-[1,2,4]triazolo[4,3-a]pyridine | HCID 55267245 | — |
반응 단계
(5-Fluoro-pyridin-2-yl)-hydrazine (500 mg, 3.93 mmol) in diethoxymethyl acetate (5 mL) was stirred at RT for 2 h. The resulting precipitate was diluted with cyclohexane (5 mL) and filtered to give Intermediate Fa (379 mg, 70%). 1H NMR (400 MHz, CDCl3): 7.25 (1H, m), 7.84 (1H, m), 8.09 (1H, t, J=2.5 Hz), 8.84 (1H, s).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09440974B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-6393d376a55a4ea7ba21b4b22cbd189c |
| 출처 메모 | uspto-grants-2016_09 |