1,2-Dichloroethane → N-(5-furan-2-yl-isoxazol-3-yl)-3-pyridin-2-yl-acrylamide

HRID 606282노트

반응식

HRID 606282 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[CH:8][C:9]([OH:11])=O.[O:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:17]1[O:21][N:20]=[C:19]([NH2:22])[CH:18]=1.C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl>CN(C=O)C>[O:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:17]1[O:21][N:20]=[C:19]([NH:22][C:9](=[O:11])[CH:8]=[CH:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH:18]=1

참가 물질

6

반응물 4

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 2478243-(2-Pyridyl)acrylic acidHCID 132302595-(Furan-2-yl)isoxazol-3-amine

생성물 1

HCID 67047568N-(5-furan-2-yl-isoxazol-3-yl)-3-pyridin-2-yl-acrylamide수율 36%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 6 mg of 3-pyridin-2-yl-acrylic acid and 6 mg of 5-furan-2-yl-isoxazol-3-ylamine in DMF were added 8 mg of HOBt, 9 mg of EDC and 0.014 mL of TEA. The reaction solution was stirred for 18 hrs at room temperature, followed by concentration under reduced pressure. The concentrate was purified by preparative HPLC to provide 4 mg of N-(5-furan-2-yl-isoxazol-3-yl)-3-pyridin-2-yl-acrylamide. (Yield: 36%).

후처리

  1. concentrationfollowed by concentration under reduced pressure
  2. customThe concentrate was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-b668bced9f59491b94c4f4a2666273b0
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915297B2

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