1-Acetylpiperazine → 4-acetyl-piperazine-1-carboxylic acid 5-furan-2-yl-isoxazol-3-ylmethyl Ester

HRID 606289노트

반응식

HRID 606289 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[O:10][N:9]=[C:8]([CH2:11][O:12][C:13](N2C=CN=C2)=[O:14])[CH:7]=1.[N:20]1([C:26](=[O:28])[CH3:27])[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>C(Cl)Cl>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[O:10][N:9]=[C:8]([CH2:11][O:12][C:13]([N:23]2[CH2:24][CH2:25][N:20]([C:26](=[O:28])[CH3:27])[CH2:21][CH2:22]2)=[O:14])[CH:7]=1

참가 물질

4

반응물 2

HCID 837951-AcetylpiperazineHCID 57696236imidazole-1-carboxylic Acid 5-furan-2-yl-isoxazol-3-ylmethyl Ester

생성물 1

HCID 576961824-acetyl-piperazine-1-carboxylic acid 5-furan-2-yl-isoxazol-3-ylmethyl Ester수율 81.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 30 mg of imidazole-1-carboxylic acid 5-furan-2-yl-isoxazol-3-ylmethyl ester in 1 mL of methylene chloride was added 16 mg of 1-piperazin-1-yl-ethanone. After stirring at room temperature for 4 hrs, the reaction mixture was concentrated under reduced pressure. The concentrate was purified by column chromatography to afford 30 mg of the title compound. (Yield: 79%).

후처리

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customThe concentrate was purified by column chromatography

출처 및 근거

ORD 기록
ord-28a4cc96b854427eb264c5c5e8072595
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915297B2

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