5,8-Difluoro-2H-chromene → 5,7-Difluoro-2H-chromene

반응식

FC1C=CC(F)=C2C=1C=CCO2.[F:13][C:14]1[CH:19]=[C:18]([O:20][CH2:21][C:22]#[CH:23])[CH:17]=[C:16]([F:24])[CH:15]=1>>[F:13][C:14]1[CH:15]=[C:16]([F:24])[CH:17]=[C:18]2[C:19]=1[CH:23]=[CH:22][CH2:21][O:20]2

참가 물질

반응물 2

HCID 224828145,8-Difluoro-2H-chromene

HCID 224828501,3-Difluoro-5-(prop-2-yn-1-yloxy)benzene

생성물 1

HCID 224828555,7-Difluoro-2H-chromene수율 23%

실험 절차

This compound was prepared analogously to 5,8-difluoro-2H-chromene but using (18 g, 107 mmol) of 1,3-difluoro-5-prop-2-ynyloxybenzene and PEG-200 as solvent to give the title compound (4 g, 23%).

출처 및 근거

ORD 기록: ord-e78e04dc8f4c4d84967c3e134141c6ee
출처 데이터셋: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07915295B2

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