6-Methoxy-1,2,3,4-tetrahydronaphthalen-1-ol → 7-Methoxy-1,2-dihydronaphthalene
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9](O)[CH2:8][CH2:7][CH2:6]2>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10]([CH:9]=[CH:8][CH2:7][CH2:6]2)=[CH:11][CH:12]=1참가 물질
3
반응 조건
- 온도
- 115 °C
실험 절차
Crude 6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol (10.3 g, 0.058 mol) was dissolved in 100 ml of toluene and heated in an oil bath (115° C.). P-tolylsulphonic acid (20 mg) was added to the reaction mixture and it was refluxed for about 1 h. The reaction was monitored by GC. The reaction mixture was then cooled and washed with sat. NaHCO3 solution, water and brine and organic layer was dried over Na2SO4. Concentration gave 8.879 of light brown oil. Yield 96%.
후처리
- temperaturewas refluxed for about 1 h
- temperatureThe reaction mixture was then cooled
- washwashed with sat. NaHCO3 solution, water and brine and organic layer
- dry with materialwas dried over Na2SO4
- concentrationConcentration
- customgave 8.879 of light brown oil
출처 및 근거
- ORD 기록
- ord-22b350368a154bf89a87ab4c815cb4f1
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07915295B2
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