Potassium Carbonate → HCID 67046696, 화합물

HRID 606367노트

반응식

HRID 606367 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]#[N:10])[CH:5]=[CH:6][CH:7]=1.O.[C:12]([OH:16])(=[O:15])[CH:13]=O.C(=O)([O-])[O-].[K+:21].[K+]>CO>[C:9]([C:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[CH:3]=1)=[CH:13][C:12]([O-:16])=[O:15])#[N:10].[K+:21]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 76279m-MethylphenylacetonitrileHCID 15620607Glyoxylic acid, monohydrate

생성물 1

HCID 67046696HCID 67046696, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirred solution of (3-methylphenyl)-acetonitrile (21.6 ml, 165 mmol) in methanol (500 ml) were added glyoxylic acid hydrate (22.7 g, 247 mmol) and potassium carbonate (57.0 g, 412 mmol). The reaction mixture was stirred at room temperature for 2 hours followed by 3 hours at reflux. The precipitate was filtered off, washed with methanol (300 ml), dichloromethane (DCM) (300 ml) and then dried under air suction. The desired product was obtained as a white solid which was used in the next step without further purification.

후처리

  1. waitfollowed by 3 hours
  2. temperatureat reflux
  3. filtrationThe precipitate was filtered off
  4. washwashed with methanol (300 ml), dichloromethane (DCM) (300 ml)
  5. customdried under air suction

출처 및 근거

ORD 기록
ord-8a49724fa3864666a18aea7e24c2e0b6
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915304B2

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