Sodium ethoxide → HCID 178470798, 화합물
반응식
[NH2:1][C:2]([NH:4][NH:5][C:6](=O)[CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[S:3].[O-]CC.[Na+]>C(O)C>[SH:3][C:2]1[NH:4][N:5]=[C:6]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:1]=1참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
A suspension of ethyl 3-[2-(aminocarbonothioyl)hydrazino]-3-oxopropanoate (14.0 g, 68.2 mmol) and sodium ethoxide (9.52 g, 140 mmol) in ethanol (200 mL) was stirred at 80° C. for 15 hr. The mixture was concentrated under reduced pressure, and the residue was acidified with 1N hydrochloric acid, and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, and concentrated to give the title compound as an orange powder (12.2 g, 96%).
후처리
- concentrationThe mixture was concentrated under reduced pressure
- extractionextracted with ethyl acetate
- washThe organic layer was washed with saturated brine
- dry with materialdried over sodium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-1545db3bcd9e4b34940f1454171f0982
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07915267B2
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