Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → ((1-(4-Bromophenyl)hexyl)oxy)(tert-butyl)dimethylsilane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 반응물 | 1-(4-Bromophenyl)hexan-1-ol | HCID 12603086 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | ((1-(4-Bromophenyl)hexyl)oxy)(tert-butyl)dimethylsilane | HCID 57438973 | 99.6% |
반응 단계
t-Butyidimethylsilylchloride (2.49 g, 16.5 mmol) was added to a solution of the alcohol 6 (3.6 g, 14.0 mmol) and imidazole (1.91 g, 28.0 mmol) in DMF (22 mL) at 23° C. The reaction was stirred for 16 h, diluted with Et2O and washed with 1 N HCl, saturated aqueous NaHCO3 and brine. The organic portion was dried (MgSO4), filtered and concentrated in vacuo. FCC (silica gel, 100% hex) afforded 5.18 g (63%) of the silyl ether 7 as a clear, colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07915316B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-fcfdca2a10de4bdfbb3309c0b99e2259 |
| 출처 메모 | uspto-grants-2011_03 |