2-Benzofurancarboxylic acid, 5-methoxy-, ethyl ester → Ethyl 5-hydroxybenzofuran-2-carboxylate
반응식
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:8][C:7]=2[CH:16]=1>ClCCl>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:8][C:7]=2[CH:16]=1참가 물질
3
실험 절차
Ethyl 5-methoxybenzofuran carboxylate (22.7 mmol) was dissolved in dichlormethane (20 ml) and a 1.0 M solution of boron tribromide methyl sulphide complex in dichloromethane (68.1 mmol) was added. The mixture was heated at reflux over night The solvent was evaporated under vacuo and the residue purified by flash chromatography to obtain ethyl 5-hydroxybenzofuran carboxylate as a white solid.
후처리
- temperatureThe mixture was heated
- temperatureat reflux over night The solvent
- customwas evaporated under vacuo
- customthe residue purified by flash chromatography
출처 및 근거
- ORD 기록
- ord-9919d0ed1faa48e0997bfb8a70d6c37d
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07915300B2
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