2-Benzofurancarboxylic acid, 5-methoxy-, ethyl ester → Ethyl 5-hydroxybenzofuran-2-carboxylate

HRID 606580

반응식

HRID 606580 반응식
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:8][C:7]=2[CH:16]=1>ClCCl>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:8][C:7]=2[CH:16]=1

참가 물질

3

반응물 1

HCID 5212832-Benzofurancarboxylic acid, 5-methoxy-, ethyl ester

생성물 1

HCID 22228632Ethyl 5-hydroxybenzofuran-2-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Ethyl 5-methoxybenzofuran carboxylate (22.7 mmol) was dissolved in dichlormethane (20 ml) and a 1.0 M solution of boron tribromide methyl sulphide complex in dichloromethane (68.1 mmol) was added. The mixture was heated at reflux over night The solvent was evaporated under vacuo and the residue purified by flash chromatography to obtain ethyl 5-hydroxybenzofuran carboxylate as a white solid.

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux over night The solvent
  3. customwas evaporated under vacuo
  4. customthe residue purified by flash chromatography

출처 및 근거

ORD 기록
ord-9919d0ed1faa48e0997bfb8a70d6c37d
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915300B2

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