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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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N-formyl-L-leucine 1-[(trans-3-hexyl-4-oxo-2-oxetanyl)methyl]-4-pentenyl ester → N-formyl-L-leucine 1-[(trans-3-hexyl-4-oxo2-oxetanyl]-methyl]pentyl ester

HRID 6066
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HRID 6066 반응식
[CH2:1]([C@@H:7]1[C:10](=[O:11])[O:9][C@H:8]1[CH2:12][CH:13]([O:18][C:19](=[O:28])[C@H:20]([CH2:24][CH:25]([CH3:27])[CH3:26])[NH:21][CH:22]=[O:23])[CH2:14][CH2:15][CH:16]=[CH2:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[H][H]>C1COCC1.[Pd]>[CH2:1]([C@@H:7]1[C:10](=[O:11])[O:9][C@H:8]1[CH2:12][CH:13]([O:18][C:19](=[O:28])[C@H:20]([CH2:24][CH:25]([CH3:26])[CH3:27])[NH:21][CH:22]=[O:23])[CH2:14][CH2:15][CH2:16][CH3:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]
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참가 물질

5

반응물 2

HCID 86743995N-formyl-L-leucine 1-[(trans-3-hexyl-4-oxo-2-oxetanyl)methyl]-4-pentenyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 86743994N-formyl-L-leucine 1-[(trans-3-hexyl-4-oxo2-oxetanyl]-methyl]pentyl ester

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 10 mg of N-formyl-L-leucine 1-[(trans-3-hexyl-4-oxo-2-oxetanyl)methyl]-4-pentenyl ester in 0.5 ml of THF was treated with 2.5 mg of 5% Pd/C and hydrogenated. After the hydrogen uptake was finished the catalyst was filtered off and the filtrate was evaporated in vacuo. The residue was chromatographed over silica gel with toluene/ethyl acetate (8:2) and there was obtained amorphous N-formyl-L-leucine 1-[(trans-3-hexyl-4-oxo-2-oxetanyl]-methyl]pentyl ester as a mixture of 2 diastereomers.

후처리

  1. filtrationwas filtered off
  2. customthe filtrate was evaporated in vacuo
  3. customThe residue was chromatographed over silica gel with toluene/ethyl acetate (8:2)

출처 및 근거

ORD 기록
ord-07a20e79c2184112a21669dbf5ac6d48
출처 데이터셋
uspto-grants-1993_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05246960

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