Dimethylformamide → 2,6-Diisopropyl-4-bromobenzaldehyde

HRID 606702노트

반응식

HRID 606702 반응식
I[C:2]1[C:7]([CH:8]([CH3:10])[CH3:9])=[CH:6][C:5]([Br:11])=[CH:4][C:3]=1[CH:12]([CH3:14])[CH3:13].[Li]CCCC.CN([CH:23]=[O:24])C>C1(C)C=CC=CC=1>[CH:12]([C:3]1[CH:4]=[C:5]([Br:11])[CH:6]=[C:7]([CH:8]([CH3:10])[CH3:9])[C:2]=1[CH:23]=[O:24])([CH3:14])[CH3:13]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 574376675-Bromo-2-iodo-1,3-diisopropylbenzeneHCID 178418339Butyllithium

생성물 1

HCID 574376682,6-Diisopropyl-4-bromobenzaldehyde

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

A 150 mL of dry toluene solution of 1-iodo-2,6-diisopropyl-4-bromobenzene (17.6 g, 0.048 mol) was treated with n-BuLi (1.6 M in hexane, 75 mL) at −78° C. in 30 minutes. After stirring for 15 minutes, dry DMF (20 mL) in 50 mL of toluene was added dropwise. The resulting mixture was slowly warmed up to room temperature. After regular work up, the crude product was distilled at 140° C. under vacuum to afford 2,6-diisopropyl-4-bromobenzaldehyde (11.5 g).

후처리

  1. distillationAfter regular work up, the crude product was distilled at 140° C. under vacuum

출처 및 근거

ORD 기록
ord-83f2cd64b82b41b19a1907869aadbef6
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915415B2

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