Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Heptanethiol → 4-[1-Phenyl-1-(5-(azetidin-3-yl)-1,3,4-oxadiazol-2-yl)methylene]piperidine-1-carboxylic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Heptanethiol | HCID 15422 | — |
| 반응물 | 4-[1-Phenyl-1-(5-(N-(9-fluorenylmethoxycarbonyl)azetidin-3-yl)-1,3,4-oxadiazol-2-yl)methylene]piperidine-1-carboxylic acid tert-butyl ester | HCID 67046374 | — |
| 촉매 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-[1-Phenyl-1-(5-(azetidin-3-yl)-1,3,4-oxadiazol-2-yl)methylene]piperidine-1-carboxylic acid tert-butyl ester | HCID 67046441 | 74.7% |
반응 단계
To a solution of 4-[1-phenyl-1-(5-(N-(9-fluorenylmethoxycarbonyl)azetidin-3-yl)-1,3,4-oxadiazol-2-yl)methylene]piperidine-1-carboxylic acid tert-butyl ester (0.161 g, 0.260 mmol) and heptanethiol (0.398 mL, 2.60 mmol) in THF (2.6 mL) at rt was added DBU (2 drops). The mixture was allowed to stir for 18 h and then the solvent was removed in vacuo. The residue was dissolved in MeOH and purified by preparative HPLC(NH4OAc) to afford the title compound (0.077 g, 74%) as a colorless solid:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07915283B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-f07e2eb3b3584e88a06d480a4bf456e3 |
| 출처 메모 | uspto-grants-2011_03 |