Tributyltin Chloride → 1-Methyl-4-(tributylstannyl)-1H-imidazole

HRID 606765노트

반응식

HRID 606765 반응식
I[C:2]1[N:3]=[CH:4][N:5]([CH3:7])[CH:6]=1.CC[Mg+].[Br-].[Sn:12](Cl)([CH2:21][CH2:22][CH2:23][CH3:24])([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:13][CH2:14][CH2:15][CH3:16]>C(Cl)Cl>[CH2:21]([Sn:12]([CH2:13][CH2:14][CH2:15][CH3:16])([CH2:17][CH2:18][CH2:19][CH3:20])[C:2]1[N:3]=[CH:4][N:5]([CH3:7])[CH:6]=1)[CH2:22][CH2:23][CH3:24]

참가 물질

5

반응물 3

HCID 15096Tributyltin ChlorideHCID 27734634-Iodo-1-methyl-1H-imidazoleHCID 178461630HCID 178461630, 화합물

생성물 1

HCID 219011411-Methyl-4-(tributylstannyl)-1H-imidazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-iodo-1-methylimidazole (0.424 g, 2.04 mmol) in CH2Cl2 at rt was added EtMgBr (3.0 M in Et2O, 0.75 mL, 2.25 mmol) and the resulting solution was allowed to stir for 30 min at rt. To this solution was then added Bu3SnCl (0.60 mL, 2.21 mmol) and the mixture was stirred for another 7 h. The resulting mixture was then washed (sat. NH4C1, H2O, brine), dried (Na2SO4) and evaporated to give the title compound, which was used directly in the following step without further purification:

후처리

  1. washThe resulting mixture was then washed (sat. NH4C1, H2O, brine)
  2. dry with materialdried (Na2SO4)
  3. customevaporated

출처 및 근거

ORD 기록
ord-1f3d29f8c7894ad3968306321295ad7c
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915283B2

반응 노트

불러오는 중…