참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Tributylvinyltin | HCID 81998 | — |
| 반응물 | 5-Bromonicotinonitrile | HCID 736793 | — |
| 촉매 | HCID 178419050 | HCID 178419050 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 5-Vinylnicotinonitrile | HCID 67047575 | 70.3% |
반응 단계
Add bis(triphenylphosphine)palladium (II) dichloride (0.460 g, 0.66 mmol) and tributyl-vinyl-stannane (7.2 mL, 24.6 mmol) to a solution of 5-bromonicotinonitrile (3.0 g, 16.4 mmol) in toluene (50 mL) and stir at 110° C. for 150 min. Add an aqueous saturated solution of ammonium chloride and ethyl acetate and separate the layers. Wash the organic layer twice with an aqueous saturated solution of potassium fluoride and once with water. Dry (sodium sulfate), filter, and concentrate. Purify the residue by silica gel chromatography, eluting with 3:1 hexane:ethyl acetate, to give the title compound (1.5 g, 70%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07915424B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_03 |
|---|
| ORD ID | ord-56b43414d3494c388f5d80d9389fb119 |
|---|
| 출처 메모 | uspto-grants-2011_03 |
|---|
