Dimethylformamide → 5-(4-Fluorophenylethynyl)-pyridine-3-carbaldehyde

HRID 606879노트

반응식

C([Mg]Cl)(C)C.[O:6]1CCC[CH2:7]1.Br[C:12]1[CH:13]=[N:14][CH:15]=[C:16]([C:18]#[C:19][C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)[CH:17]=1.CN(C)C=O>>[F:26][C:23]1[CH:24]=[CH:25][C:20]([C:19]#[C:18][C:16]2[CH:17]=[C:12]([CH:7]=[O:6])[CH:13]=[N:14][CH:15]=2)=[CH:21][CH:22]=1

참가 물질

반응물 4

HCID 6228Dimethylformamide

HCID 8028Tetrahydrofuran

HCID 670476153-Bromo-5-(4-fluorophenylethynyl)-pyridine

HCID 178418918HCID 178418918, 화합물

생성물 1

HCID 860764705-(4-Fluorophenylethynyl)-pyridine-3-carbaldehyde수율 24%

실험 절차

Prepare in a similar manner as described in EXAMPLE 90, using a 2 M solution of isopropylmagnesium chloride in tetrahydrofuran (2.99 mL, 5.98 mmol), 3-bromo-5-(4-fluorophenylethynyl)-pyridine (1.50 g, 5.43 mmol), (prepared essentially as described in EXAMPLE 96), and anhydrous N,N-dimethylformamide (1.99 g, 27.16 mmol) to give the title compound (0.29 g, 24%).

후처리

customPrepare in a similar manner
custom(prepared essentially

출처 및 근거

ORD 기록: ord-0fbfbc71b9504dfcb13a38ab6e4b5497
출처 데이터셋: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07915424B2

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