Sodium Iodide → Benzonitrile, 4-[(5-iodopentyl)oxy]-

HRID 6069

반응식

HRID 6069 반응식
Cl[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][CH:9]=1.[I-:16].[Na+]>CC(C)=O>[I:16][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 193815104-((5-Chloropentyl)oxy)benzonitrile

생성물 1

HCID 16202445Benzonitrile, 4-[(5-iodopentyl)oxy]-

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

To a solution of 32.7 g (146 mmol) of 4-(5-chloropentoxy) benzonitrile in 350 mL acetone is added 38.3 g (150 mmol) of sodium iodide in 230 mL of acetone. The reaction is heated to reflux and stirred overnight. The acetone is removed under reduced pressure and the residue partitioned between water and ether. The ethereal layer is dried, filtered and evaporated to give 4-(5-iodopentoxy) benzonitrile, m.p. 51°-54° C.

후처리

  1. temperatureThe reaction is heated
  2. temperatureto reflux
  3. customThe acetone is removed under reduced pressure
  4. customthe residue partitioned between water and ether
  5. customThe ethereal layer is dried
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-adbf3dc1a5cb462d9cbba9a96dc56869
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05246965

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