Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Fluoro-5-trimethylsilanylethynyl-phenylamine → 5-(3-Amino-4-fluorophenylethynyl)-nicotinonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Fluoro-5-trimethylsilanylethynyl-phenylamine | HCID 67047696 | — |
| 반응물 | 3-Bromonicotinonitrile | HCID 67047774 | — |
| 생성물 | 5-(3-Amino-4-fluorophenylethynyl)-nicotinonitrile | HCID 67047822 | 65% |
반응 단계
Prepare essentially as described in EXAMPLE 138 using 3-bromonicotinonitrile (3.4 g, 18.3 mmol) and 2-fluoro-5-trimethylsilanylethynyl-phenylamine, (prepared as described in PREPARATION 41), (3.8 g, 18.3 mmol) to give the title compound as a white solid (2.8 g, 65%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07915424B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-00547915240f429085bf9f6c5be4190d |
| 출처 메모 | uspto-grants-2011_03 |