Iodide Ion → Methyl 2'-fluoro-5'-iodo-4'-methoxy-3-methylbiphenyl-4-carboxylate

HRID 607112노트

반응식

HRID 607112 반응식
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([C:16]([O:18][CH3:19])=[O:17])=[C:12]([CH3:20])[CH:11]=1.[I-:21]>S([O-])([O-])(=O)=O.[Ag+2].CO>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([I:21])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([C:16]([O:18][CH3:19])=[O:17])=[C:12]([CH3:20])[CH:11]=1

참가 물질

5

반응물 2

HCID 30165Iodide IonHCID 57704853Methyl 2'-fluoro-4'-methoxy-3-methylbiphenyl-4-carboxylate

생성물 1

HCID 57704857Methyl 2'-fluoro-5'-iodo-4'-methoxy-3-methylbiphenyl-4-carboxylate

시약·촉매·용매 2

HCID 178418844HCID 178418844, 화합물촉매HCID 887Methanol용매

실험 절차

methyl 2′-fluoro-4′-methoxy-3-methylbiphenyl-4-carboxylate (100 mg, 0.365 mmol), methanol (3 mL), iodide (93 mg, 0.366 mmol) and silver sulfate (114 mg, 0.366 mmol) were stirred at room temperature for 1.5 hours. Reaction crude was quenched by Na2SO3 (sat., aq.). Volatiles were removed from the grayish brown mixture. The pot residue was worked up with H2O/EtOAc/Na2SO4/filtration/concentration to afford the title compound. LCMS (ESI) calc.=400.00; found=400.96 (M+1)+.

후처리

  1. customReaction crude
  2. customwas quenched by Na2SO3 (sat., aq.)
  3. customVolatiles were removed from the grayish brown mixture
  4. concentrationThe pot residue was worked up with H2O/EtOAc/Na2SO4/filtration/concentration

출처 및 근거

ORD 기록
ord-2447c2be3b16402e91e5756c7287894d
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915271B2

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