N-[4-(2-Amino-4-methyl-phenylsulfanyl)-phenyl]-acetamide → N-[4-[2-[(7-cyclopropylpyrido[2,3-d]pyrimidin-4-yl)amino]-4-methyl-phenyl]sulfanylphenyl]acetamide

HRID 607229노트

반응식

HRID 607229 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[S:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:19])[CH3:18])=[CH:12][CH:11]=1.C([C:22]1[C:23]([N:31]=[CH:32][N:33]([CH3:35])C)=[N:24][C:25]([CH:28]2[CH2:30][CH2:29]2)=[CH:26][CH:27]=1)#N.NC1C=C(C)C=CC=1SC1C=CC(O)=CC=1.C(C1C(N=CN(C)C)=NC(C)=CC=1)#N>>[CH:28]1([C:25]2[CH:26]=[CH:27][C:22]3[C:35]([NH:1][C:2]4[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=4[S:9][C:10]4[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:19])[CH3:18])=[CH:12][CH:11]=4)=[N:33][CH:32]=[N:31][C:23]=3[N:24]=2)[CH2:29][CH2:30]1

참가 물질

5

반응물 4

HCID 43168935N-[4-(2-Amino-4-methyl-phenylsulfanyl)-phenyl]-acetamide2회HCID 668081234-(2-Amino-4-methyl-phenylsulfanyl)-phenolHCID 66808412N'-(3-Cyano-6-cyclopropyl-pyridin-2-yl)-N,N-dimethyl-formamidine2회HCID 66808573N'-(3-Cyano-6-methyl-pyridin-2-yl)-N,N-dimethyl-formamidine

생성물 1

HCID 57394885N-[4-[2-[(7-cyclopropylpyrido[2,3-d]pyrimidin-4-yl)amino]-4-methyl-phenyl]sulfanylphenyl]acetamide

실험 절차

The product from Example 7b was reacted with the product from Example 119A using the procedure from Example 102 substituting the product from Example 7b for the product from Example 6c and substituting the product from Example 119A for the product from Example 10B to provide the crude residue which was purified by trituration with methanol to provide the title compound. 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.13 (d, J=6.25 Hz, 4H), 2.02 (s, 3H), 2.22-2.38 (m, 1H), 2.31 (s, 3H), 7.07 (s, 2H), 7.20 (d, J=8.82 Hz, 2H), 7.30 (s, 1H), 7.50 (d, J=8.82 Hz, 2H), 7.56 (d, J=8.46 Hz, 1H), 8.49 (s, 1H), 8.68 (d, J=8.82 Hz, 1H), 9.99 (s, 2H); MS (ESI+) m/z 442 (M+H)+.

후처리

  1. customto provide the crude residue which
  2. customwas purified by trituration with methanol

출처 및 근거

ORD 기록
ord-05107f435f354978aaffea2af132e178
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915411B2

반응 노트

불러오는 중…