2-iodo-1H-imidazole → (S)-5-(1H-imidazol-2-ylethynyl)-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide

HRID 607364노트

반응식

HRID 607364 반응식
[C:1]([C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:20]=1)[C:8]([N:10]=[S@@:11]([CH3:19])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])#[CH:2].I[C:22]1[NH:23][CH:24]=[CH:25][N:26]=1>>[NH:23]1[CH:24]=[CH:25][N:26]=[C:22]1[C:2]#[C:1][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:20]=1)[C:8]([N:10]=[S@@:11]([CH3:19])(=[O:18])[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:9]

참가 물질

3

반응물 2

HCID 27734682-iodo-1H-imidazoleHCID 24953136(S)-5-ethynyl-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide

생성물 1

HCID 86629468(S)-5-(1H-imidazol-2-ylethynyl)-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide수율 29%

실험 절차

In a manner similar to that describe in Example 434, a mixture of (S)-5-ethynyl-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide and 2-iodo-1H-imidazole were reacted to give the title compound as a white solid (15 mg, 29%).

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-0069c148104348e7adccb155949eb00c
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915443B2

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