Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → (S)-5-Oxotetrahydrofuran-2-carbonyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | (2S)-5-oxooxolane-2-carboxylic acid | HCID 636468 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (S)-5-Oxotetrahydrofuran-2-carbonyl chloride | HCID 10975648 | 87.4% |
반응 단계
To a solution of (2S)-5-oxotetrahydrofuran-2-carboxylic acid (compound 28a, 70 g, 539 mmol) and a drop of DMF in anhydrous DCM (500 mL) was added oxalyl dichloride (137 g, 1.07 mol) dropwise. The reaction mixture was stirred at room temperature for 3 hours. The reaction was then concentrated in vacuo to afford 70 g crude product of (2S)-5-oxotetrahydrofuran-2-carbonyl chloride (compound 28b), which was used in next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09441008B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-77eed8f0a2d446d19676e36e967d82c0 |
| 출처 메모 | uspto-grants-2016_09 |