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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 607457생성일: 2026년 10월 25일

1-(2-Hydroxyethyl)piperazine → (S)-N-[{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide

https://huagongshe.com/reaction/607457

반응식

참여 물질

역할이름HCID투입량
반응물1-(2-Hydroxyethyl)piperazineHCID 7677—
반응물N-[(3-bromopropyl)(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamideHCID 76585264—
생성물(S)-N-[{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamideHCID 57657889—

반응 단계

In a manner similar to that described for Example 508, N-[(3-bromopropyl)(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide and 1-piperazineethanol were converted to the title compound.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07915443B2
출처 데이터셋uspto-grants-2011_03
ORD IDord-f53de5b0781447f6b9bd3b77abcb10bc
출처 메모uspto-grants-2011_03