Trifluoroacetic acid → (2S)-3,3-dimethyl-2-({4-[3-(1-quinolin-6-ylcyclopropyl)[1,2,4]triazolo[4,3-b][1,2,4]triazin-6-yl]benzoyl}amino)butanoic acid

HRID 607601노트

반응식

HRID 607601 반응식
C([O:5][C:6](=[O:43])[C@@H:7]([NH:12][C:13](=[O:42])[C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[N:22][C:23]3[N:24]([C:26]([C:29]4([C:32]5[CH:33]=[C:34]6[C:39](=[CH:40][CH:41]=5)[N:38]=[CH:37][CH:36]=[CH:35]6)[CH2:31][CH2:30]4)=[N:27][N:28]=3)[N:25]=2)=[CH:16][CH:15]=1)[C:8]([CH3:11])([CH3:10])[CH3:9])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:9][C:8]([CH3:11])([CH3:10])[C@H:7]([NH:12][C:13](=[O:42])[C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:21]=[N:22][C:23]3[N:24]([C:26]([C:29]4([C:32]5[CH:33]=[C:34]6[C:39](=[CH:40][CH:41]=5)[N:38]=[CH:37][CH:36]=[CH:35]6)[CH2:30][CH2:31]4)=[N:27][N:28]=3)[N:25]=2)=[CH:18][CH:19]=1)[C:6]([OH:43])=[O:5]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 59216337Tert-butyl-(2S)-3,3-dimethyl-2-({4-[3-(1-quinolin-6-ylcyclopropyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-6-yl]benzoyl}amino)butanoate

생성물 1

HCID 59216331(2S)-3,3-dimethyl-2-({4-[3-(1-quinolin-6-ylcyclopropyl)[1,2,4]triazolo[4,3-b][1,2,4]triazin-6-yl]benzoyl}amino)butanoic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Tert-butyl-(2S)-3,3-dimethyl-2-({4-[3-(1-quinolin-6-ylcyclopropyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-6-yl]benzoyl}amino)butanoate was dissolved in methylene chloride (0.7 ml). To the solution was added TFA (0.7 ml). The mixture was stirred for 1.5 h. The volatiles were removed under reduced pressure to yield the desired product. Analytical LCMS: (M+H)+=522.2.

후처리

  1. customThe volatiles were removed under reduced pressure

출처 및 근거

ORD 기록
ord-a0c948b763c34302954cec616f160650
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915408B2

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