p-Toluenesulfonic acid monohydrate → HCID 59216307, 화합물
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[F:1][C:2]1[CH:11]=[C:10]([C:12](=[O:15])[CH:13]=[O:14])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].C([O-])([O-])[O:17][CH2:18][CH3:19].O.[C:23]1(C)C=CC(S(O)(=O)=O)=C[CH:24]=1>C1(C)C=CC=CC=1>[CH2:23]([O:14][CH:13]([O:17][CH2:18][CH3:19])[C:12]([C:10]1[CH:9]=[CH:8][C:3]([C:4]([O:6][CH3:7])=[O:5])=[C:2]([F:1])[CH:11]=1)=[O:15])[CH3:24]참가 물질
5
실험 절차
A mixture of methyl 2-fluoro-4-(oxoacetyl)benzoate (1.60 g), ethyl orthoformate (5.2 mL), p-toluenesulfonic acid monohydrate (70 mg) in toluene (20 mL) was heated under reflux for 3 h. After cooling, the mixture was concentrated. The residue was flash chromatographed on a silica gel column to give the desired product (0.63 g).
후처리
- temperaturewas heated
- temperatureunder reflux for 3 h
- temperatureAfter cooling
- concentrationthe mixture was concentrated
- customchromatographed on a silica gel column
출처 및 근거
- ORD 기록
- ord-426360c601344ead88315066ce8217ec
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07915408B2
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