Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 60798생성일: 2026년 10월 25일
Diisopropylethylamine → rac-cis-(2-(((5-Ethylpyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone
https://huagongshe.com/reaction/60798
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Chloro-5-ethylpyrimidine | HCID 3572763 | — |
| 반응물 | Rac-cis-(2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone | HCID 117727897 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | rac-cis-(2-(((5-Ethylpyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone | HCID 131737126 | — |
반응 단계
A mixture of rac-cis-(2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone, 5-ethyl-2-chloropyrimidine, and DIPEA in isopropanol was stirred at 110° C. for 18 h. The reaction was cooled and concentrated in vacuo. The crude reaction mixture was purified by reverse-phase preparative HPLC to afford the title compound. MS (ESI) 454.02 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09440982B2 |
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| 출처 데이터셋 | uspto-grants-2016_09 |
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| ORD ID | ord-aa260a00d23b419894ac9bc950ccb827 |
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| 출처 메모 | uspto-grants-2016_09 |
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