Trifluoroacetic acid → N-((1-(Biphenylcarbonyl)-5-oxopiperidin-2-yl)methyl)quinoline-8-carboxamide

HRID 60813

반응식

HRID 60813 반응식
N1C2C(=CC=CC=2C(O)=O)C=CC=1.[C:14]1([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[C:15]([C:20]([N:22]2[CH:27]=[C:26]([O:28]C)[CH2:25][CH2:24][CH:23]2[CH2:30][NH:31][C:32]([C:34]2[CH:35]=[CH:36][CH:37]=[C:38]3[C:43]=2[N:42]=[CH:41][CH:40]=[CH:39]3)=[O:33])=[O:21])=[CH:16][CH:17]=[CH:18][CH:19]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:14]1([C:44]2[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=2)[C:15]([C:20]([N:22]2[CH2:27][C:26](=[O:28])[CH2:25][CH2:24][CH:23]2[CH2:30][NH:31][C:32]([C:34]2[CH:35]=[CH:36][CH:37]=[C:38]3[C:43]=2[N:42]=[CH:41][CH:40]=[CH:39]3)=[O:33])=[O:21])=[CH:16][CH:17]=[CH:18][CH:19]=1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 665828-Quinolinecarboxylic acidHCID 89740834N-((1-(biphenylcarbonyl)-5-methoxy-1,2,3,4-tetrahydropyridin-2-yl)methyl)quinoline-8-carboxamide

생성물 1

HCID 89739334N-((1-(Biphenylcarbonyl)-5-oxopiperidin-2-yl)methyl)quinoline-8-carboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

N-((1-(Biphenylcarbonyl)-5-oxopiperidin-2-yl)methyl)quinoline-8-carboxamide was prepared according general procedure A using quinoline-8-carboxylic acid and N-((1-(biphenylcarbonyl)-5-methoxy-1,2,3,4-tetrahydropyridin-2-yl)methyl)quinoline-8-carboxamide which was synthesized from the product from Part VI above, following ketal cleavage using TFA and CH2Cl2. MS (ESI) 464 (M+H).

출처 및 근거

ORD 기록
ord-79d459c41a05423997f37c19c5489e52
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440982B2

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