Methanol → Methyl 2-bromo-5-methylbenzoate

HRID 60888

반응식

HRID 60888 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].OS(O)(=O)=O.[CH3:17]O>>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([O:6][CH3:17])=[O:5]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 2280802-Bromo-5-methylbenzoic acid

생성물 1

HCID 15110996Methyl 2-bromo-5-methylbenzoate

반응 조건

온도
100 °C

실험 절차

2-Bromo-5-methylbenzoic acid (9.3 g, 43.4 mmol) was dissolved in MeOH (100 mL) and then cat. conc. H2SO4 was added. The mixture was refluxed at 100° C. overnight. The mixture was cooled to rt and the solvent was removed at reduced pressure. The crude residue was dissolved with EtOAc, and washed with water twice, followed by saturated NaHCO3 and brine, dried over anhydrous Na2SO4. The solvent was removed in vacuo to obtain the title compound with no further purification.

후처리

  1. temperatureThe mixture was cooled to rt
  2. customthe solvent was removed at reduced pressure
  3. dissolutionThe crude residue was dissolved with EtOAc
  4. washwashed with water twice
  5. dry with materialdried over anhydrous Na2SO4
  6. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-f3beddf5a050465f840bd0014af2be0c
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440982B2

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