2-Methoxy-2,4,6-cycloheptatrien-1-one → 2-(4-Piperonyl-1-piperazinyl)-2,4,6-cycloheptatriene-1-one

HRID 609584

반응식

HRID 609584 반응식
CO[C:3]1[C:9](=[O:10])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:11]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[C:12]1[CH:20]=[CH:19][C:18]2[O:17][CH2:16][O:15][C:14]=2[CH:13]=1>CO>[CH2:11]([N:21]1[CH2:26][CH2:25][N:24]([C:3]2[C:9](=[O:10])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH2:23][CH2:22]1)[C:12]1[CH:20]=[CH:19][C:18]2[O:17][CH2:16][O:15][C:14]=2[CH:13]=1

참가 물질

4

반응물 2

HCID 165462-Methoxy-2,4,6-cycloheptatrien-1-oneHCID 944261-Piperonylpiperazine

생성물 1

HCID 98402272-(4-Piperonyl-1-piperazinyl)-2,4,6-cycloheptatriene-1-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2-methoxytropone (1.36 g, 10.0 mmol) (Pietra, F. Chem Review, 1973, 73:293) and 1-piperonylpiperazine (6.61 g, 30.0 mmol) in methanol (50.0 mL) was refluxed for 16 h. After cooling to room temperature, the solvent was removed in vacuo. The residue was subjected to column chromatography using ethyl acetate as the eluent. The title compound was obtained as a yellow oil (1.24 g, 38%). MS (FAB) 325 (M+ +1).

후처리

  1. temperaturewas refluxed for 16 h
  2. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-cff103170fa347b5a3c1344cde5b35a5
출처 데이터셋
uspto-grants-1999_12
특허 번호
US05998414

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