1H-Indole-3-carboxylic acid, 2-chloro- → N-[(1-n butyl-4-piperidyl)methyl]2-chloroindole-3-carboxamide

HRID 609609

반응식

HRID 609609 반응식
[Cl:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[C:11]([OH:13])=O)=[CH:8][CH:7]=[CH:6][CH:5]=2.[CH2:14]([N:18]1[CH2:23][CH2:22][CH:21]([CH2:24][NH:25]C(C2C3C(=CC=CC=3)NC=2)=O)[CH2:20][CH2:19]1)[CH2:15][CH2:16][CH3:17]>>[CH2:14]([N:18]1[CH2:23][CH2:22][CH:21]([CH2:24][NH:25][C:11]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[NH:3][C:2]=2[Cl:1])=[O:13])[CH2:20][CH2:19]1)[CH2:15][CH2:16][CH3:17]

참가 물질

3

반응물 2

HCID 995211H-Indole-3-carboxylic acid, 2-chloro-HCID 10591304N-[(1-n butyl-4-piperidyl)methyl] indole-3-carboxamide2회

생성물 1

HCID 22096969N-[(1-n butyl-4-piperidyl)methyl]2-chloroindole-3-carboxamide

실험 절차

2-Chloroindole-3-carboxylic acid (L. Marchetti and A Andreani, Ann. Chim. (Rome), 1973, 63, 681) was converted to its acid chloride and reacted with N-(1-n butyl-4-piperidyl)methylamine (D1) using the procedure of Description 1b to afford N-[(1-n butyl-4-piperidyl)methyl]2-chloroindole-3-carboxamide.

출처 및 근거

ORD 기록
ord-a21d3270672b4aa1a7ed054c7bdf51f9
출처 데이터셋
uspto-grants-1999_12
특허 번호
US05998409

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