5-Bromo-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indole → 5-(1-hydroxycyclohex-1-yl)-3-(2-pyrrolidinylethyl)-1H-indole

HRID 609735

반응식

HRID 609735 반응식
[OH:1][C:2]1([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][CH:12]=[C:11]3[CH2:17][CH2:18][N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)[CH:7]=[CH:6]S[CH:4]=[CH:3]1.Br[C:25]1C=C2C(=CC=1)NC=C2CCN1CCCC1>>[OH:1][C:2]1([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][CH:12]=[C:11]3[CH2:17][CH2:18][N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:7][CH2:6][CH2:25][CH2:4][CH2:3]1

참가 물질

3

반응물 2

HCID 158384855-Bromo-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indoleHCID 69948946HCID 69948946, 화합물

생성물 1

HCID 699487065-(1-hydroxycyclohex-1-yl)-3-(2-pyrrolidinylethyl)-1H-indole

실험 절차

5-(4-Hydroxythiapyran-4-yl)-3-(2-pyrrolidinylethyl)-1H-indole: (56%) from 5-bromo-3-(2-pyrrolidinylethyl)-1H-indole (Example 3b); mp 66-78° C.; HRMS-FAB+ for C19H27N2OS: calculated MH+ :331.18442; found MH+ :331.18568.

출처 및 근거

ORD 기록
ord-e7a343152bb6430aad4047785ee4bbe4
출처 데이터셋
uspto-grants-1999_12
특허 번호
US05998438

연결된 노트

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