Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Isopropylaniline → 4-Isopropyl-N-(2,2-diethoxyethyl)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Isopropylaniline | HCID 7464 | — |
| 반응물 | Ethane, 2-bromo-1,1-diethoxy- | HCID 74852 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-Isopropyl-N-(2,2-diethoxyethyl)aniline | HCID 19600944 | 90.9% |
반응 단계
A solution of 4-isopropylaniline (7.6 mL, 56 mmol), 2-bromoacetaldehyde diethyl acetal (5.5 mL, 36 mmol) and sodium bicarbonate (4.8 g, 57 mmol) in ethanol (60 mL) was stirred at reflux for 3 days under argon. After cooling to room temperature, the ethanol was removed in vacuo and the product was partitioned between ether and water, washed sequentially with water and brine, and dried over sodium sulfate. After removal of the solvent in vacuo, flash chromatography (silica, 10% ethyl acetate in hexanes) yielded 4-isopropyl-N-(2,2-diethoxyethyl) aniline (8.23 g, 90%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05998462 |
| 출처 데이터셋 | uspto-grants-1999_12 |
| ORD ID | ord-4bc69996890742b593cb12a4b60e9adc |
| 출처 메모 | uspto-grants-1999_12 |