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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 610068생성일: 2026년 10월 26일

3-Amino-N-(4-bromophenyl)benzamide → 5-Benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-bromo-phenylcarbamoyl)-phenyl]-amide

https://huagongshe.com/reaction/610068

반응식

참여 물질

역할이름HCID투입량
반응물3-Amino-N-(4-bromophenyl)benzamideHCID 13609514—
반응물Ethyl 1-ethyl-5-benzoyloxindole-3-carboxylateHCID 20189466—
생성물5-Benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-bromo-phenylcarbamoyl)-phenyl]-amideHCID 54177968—

반응 단계

Prepared as in Example 1, Step A, from 5-benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid ethyl ester (U.S. Pat. No. 4,686,224) and 3-amino-N-(4-bromo-phenyl)-benzamide. Purified by flash-chromatography (hexanes/acetone, 1:1) followed by trituration in ethyl acetate/hexanes. mp 139-142° C.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US05998463
출처 데이터셋uspto-grants-1999_12
ORD IDord-5135fb3f47c14e0582bed7be8351239d
출처 메모uspto-grants-1999_12