Triethylamine → 3-(3,3-Diphenyl-ureido)-N-phenylbenzamide

HRID 610080

반응식

HRID 610080 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6].[C:17]1([N:23]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:24](Cl)=[O:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(N(CC)CC)C>C(O)C>[C:17]1([N:23]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:24](=[O:25])[NH:1][C:2]2[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=2)[C:5]([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:6])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 65741N,N-Diphenylcarbamic chlorideHCID 843473-Aminobenzanilide

생성물 1

HCID 196009793-(3,3-Diphenyl-ureido)-N-phenylbenzamide수율 42.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 3-amino-N-phenylbenzamide (2.0 g, 9.4 mmol), diphenylcarbamoyl chloride (2.2 g, 9.4 mmol) and triethylamine (2.6 mL, 19 mmol) in ethanol (10 mL) was heated to reflux for 4.5 hours. The mixture was cooled and concentrated, water was added, the slurry was acidified with 1 N HCl and the solid was collected, washed with water, dried and recrystallized from acetone/hexanes, to give a colorless solid (1.63 g, 42%).

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 4.5 hours
  3. temperatureThe mixture was cooled
  4. concentrationconcentrated
  5. additionwater was added
  6. customthe solid was collected
  7. washwashed with water
  8. customdried
  9. customrecrystallized from acetone/hexanes

출처 및 근거

ORD 기록
ord-b4ea39b9f4e54985812f70768033485a
출처 데이터셋
uspto-grants-1999_12
특허 번호
US05998463

연결된 노트

불러오는 중…