Methyl chloroformate → Benzoic acid, 4-(1-methylethenyl)-, methyl ester

HRID 610105

반응식

HRID 610105 반응식
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([CH3:8])=[CH2:7])=[CH:4][CH:3]=1.[Mg].Cl[C:13]([O:15][CH3:16])=[O:14]>C1COCC1>[C:6]([C:5]1[CH:9]=[CH:10][C:2]([C:13]([O:15][CH3:16])=[O:14])=[CH:3][CH:4]=1)([CH3:8])=[CH2:7]

참가 물질

5

반응물 3

HCID 6586Methyl chloroformateHCID 743814-Chloro-alpha-methylstyreneHCID 5462224Magnesium

생성물 1

HCID 11275336Benzoic acid, 4-(1-methylethenyl)-, methyl ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Preparation of the Grignard compound of 4-chloro-α-methylstyrene by means of Rieke magnesium in THF under reflux and subsequent reaction with 0.95 equivalents of methyl chloroformate at RT. Aqueous working up, extraction with ethyl acetate and column chromatography using cyclohexane/ethyl acetate 85:15 affords methyl 4-isopropenylbenzoate as colorless crystals.

후처리

  1. temperatureunder reflux
  2. extractionextraction with ethyl acetate and column chromatography

출처 및 근거

ORD 기록
ord-0c66f3c754bd40ea943d24950051c2a9
출처 데이터셋
uspto-grants-1999_12
특허 번호
US05998481

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