3-Phenylsalicylic acid → 2-(2,4-Dimethyl-3-pentyloxy)carbonyl-6-phenylphenol

HRID 610459

반응식

HRID 610459 반응식
CS([O:5][CH:6]([CH:10]([CH3:12])[CH3:11])[CH:7]([CH3:9])[CH3:8])(=O)=O.[C:13]1([C:19]2[CH:27]=[CH:26][CH:25]=[C:21]([C:22](O)=[O:23])[C:20]=2[OH:28])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O>[CH3:8][CH:7]([CH:6]([O:5][C:22]([C:21]1[CH:25]=[CH:26][CH:27]=[C:19]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:20]=1[OH:28])=[O:23])[CH:10]([CH3:12])[CH3:11])[CH3:9]

참가 물질

5

반응물 3

HCID 93483-Phenylsalicylic acidHCID 10340Sodium CarbonateHCID 54447467(2,4-Dimethyl-3-pentyl) methanesulfonate

생성물 1

HCID 110560652-(2,4-Dimethyl-3-pentyloxy)carbonyl-6-phenylphenol수율 64%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In a four-neck flask having an inner volume of 100 ml, 4.86 g (25 m.mols) of (2,4-dimethyl-3-pentyl) methanesulfonate, 5.36 g (25 m.mols) of 3-phenylsalicylic acid, 2.65 g (25 m.mols) of sodium carbonate, and 50 ml of dimethyl formamide were placed and left reacting at 90° C. for three hours. After the reaction, the reaction mass was thrown into 100 ml of ice water and extracted twice with 150 ml of ethyl acetate. The organic layer obtained consequently was washed twice with 50 ml of water. Then, by distilling the organic layer thereby expelling the solvent by evaporation, 5.00 g (16 m.mols) of 2-(2,4-dimethyl-3-pentyloxy)carbonyl-6-phenylphenol was obtained as the product aimed at.

후처리

  1. customIn a four-neck flask having
  2. waitleft
  3. customAfter the reaction
  4. extractionextracted twice with 150 ml of ethyl acetate
  5. customThe organic layer obtained consequently
  6. washwas washed twice with 50 ml of water
  7. distillationThen, by distilling the organic layer
  8. customby evaporation

출처 및 근거

ORD 기록
ord-40d1a19b81ae45b9b295034e5f43b00b
출처 데이터셋
uspto-grants-1999_12
특허 번호
US05998609

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