Tetrafluorophthalonitrile → 3,5,6-Trifluoro-4-(2-(2,4-dimethyl-3-pentyloxy)carbonyl-6-phenylphenoxy)phthalonitrile

HRID 610460

반응식

HRID 610460 반응식
[F:1][C:2]1[C:9]([F:10])=[C:8](F)[C:7]([F:12])=[C:4]([C:5]#[N:6])[C:3]=1[C:13]#[N:14].[CH3:15][CH:16]([CH:18]([O:22][C:23]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:26]=1[OH:37])=[O:24])[CH:19]([CH3:21])[CH3:20])[CH3:17].[F-].[K+]>C(#N)C>[F:12][C:7]1[C:8]([O:37][C:26]2[C:27]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[CH:28][CH:29]=[CH:30][C:25]=2[C:23]([O:22][CH:18]([CH:19]([CH3:21])[CH3:20])[CH:16]([CH3:15])[CH3:17])=[O:24])=[C:9]([F:10])[C:2]([F:1])=[C:3]([C:13]#[N:14])[C:4]=1[C:5]#[N:6]

참가 물질

5

반응물 3

HCID 74600TetrafluorophthalonitrileHCID 522689Potassium FluorideHCID 110560652-(2,4-Dimethyl-3-pentyloxy)carbonyl-6-phenylphenol

생성물 1

HCID 118270963,5,6-Trifluoro-4-(2-(2,4-dimethyl-3-pentyloxy)carbonyl-6-phenylphenoxy)phthalonitrile수율 93.4%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

In a four-neck flask having an inner volume of 100 ml, 3.00 g (15 m.mols) of 3,4,5,6-tetrafluorophthalonitrile, 4.69 g (15 m.mols) of 2-(2,4-dimethyl-3-pentyloxy)carbonyl-6-phenylphenol, 2.62 g (45 m.mols) of potassium fluoride, and 50 ml of acetonitrile were placed and left reacting under reflux for six hours. After the reaction, the reaction mass was filtered and then distilled to expel the solvent by evaporation and obtain 6.90 g (14 m.mols) of 3,5,6-trifluoro-4-(2-(2,4-dimethyl-3-pentyloxy)carbonyl-6-phenylphenoxy)phthalonitrile as the product aimed at.

후처리

  1. customIn a four-neck flask having
  2. waitleft
  3. temperatureunder reflux for six hours
  4. customAfter the reaction
  5. filtrationthe reaction mass was filtered
  6. distillationdistilled
  7. customby evaporation

출처 및 근거

ORD 기록
ord-4b86f58a821b4d5791afa694cdbc2781
출처 데이터셋
uspto-grants-1999_12
특허 번호
US05998609

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