Chlorodimethylphenylsilane → n,n-Diethyl-2-chloro-6-(dimethylphenylsilyl)benzamide

반응식

[CH2:1]([N:3]([CH2:13][CH3:14])[C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:2].[CH3:15][Si:16](Cl)([CH3:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:13]([N:3]([CH2:1][CH3:2])[C:4](=[O:12])[C:5]1[C:10]([Si:16]([CH3:23])([CH3:15])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:14]

참가 물질

반응물 2

HCID 13029Chlorodimethylphenylsilane

HCID 825662-Chloro-N,N-diethylbenzamide

생성물 1

HCID 54348567n,n-Diethyl-2-chloro-6-(dimethylphenylsilyl)benzamide

실험 절차

The title compound was prepared from the compound of Example e and 1.1 eq dimethylphenylsilyl chloride according to General Method A. Purification by HPLC with 1:9 ethyl acetate/hexanes gave 6.3 g of the desired product as a clear oil, a 91% yield.

후처리

customPurification by HPLC with 1:9 ethyl acetate/hexanes

출처 및 근거

ORD 기록: ord-0a0d9b934c394363984f88c4575699c9
출처 데이터셋: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05998466

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