참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium fluoride | HCID 25953 | — |
| 반응물 | 2-(Tributylstannyl)pyridine | HCID 607784 | — |
| 반응물 | 3-Bromo-6-methylpyridine-2-carbonitrile | HCID 21952747 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 6'-Methyl-2,3'-bipyridine-2'-carbonitrile | HCID 59363716 | 88% |
반응 단계
A mixture of 3-bromo-6-methylpicolinonitrile (1 g, 5.1 mmol), 2-(tributylstannyl)pyridine (2.43 ml, 6.60 mmol), cesium fluoride (150 mg, 10.2 mmol), CuI (193 mg, 1.02 mmol) and Pd(PPh3)4 (586 mg, 0.51 mmol) in DMF (10 mL) was degassed and heated at 120° C. for 1 h in a microwave reactor. The solvent was removed in vacuo to obtain the crude which was purified by silica gel chromatography (0˜100% DCM/EtOAc) to yield the title compound as a brown oil (0.87 g, 88%). MS (ESI) 196 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09440982B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-ca8ed7fd06cf4ff3a8a7b5ac5854dc1b |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
