Triethylamine → HCID 19600240, 화합물

HRID 611255노트

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HRID 611255 반응식
[O:1]1[C:5]2[CH2:6][NH:7][CH2:8][CH2:9][C:4]=2[CH:3]=[C:2]1[C:10]([O:12][CH3:13])=[O:11].[C:14]([C:22]1[CH:30]=[CH:29][C:25]([C:26](O)=[O:27])=[CH:24][CH:23]=1)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(N(CC)CC)C.C(P(=O)(OCC)OCC)#N>ClCCl>[C:14]([C:22]1[CH:23]=[CH:24][C:25]([C:26]([N:7]2[CH2:8][CH2:9][C:4]3[CH:3]=[C:2]([C:10]([O:12][CH3:13])=[O:11])[O:1][C:5]=3[CH2:6]2)=[O:27])=[CH:29][CH:30]=1)(=[O:21])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 691474-Benzoylbenzoic acidHCID 76257Diethyl cyanophosphonateHCID 19600098Methyl 4,5,6,7-tetrahydrofuro[2,3-c]pyridine-2-carboxylate

생성물 1

HCID 19600240HCID 19600240, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 72 mg (0.40 mmol) of methyl 4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-carboxylate, 0.11 g (0.48 mmol) of 4-benzoylbenzoic acid and 0.11 ml (0.79 mmol) of triethylamine in 30 ml of dichloromethane, 0.07 ml (0.48 mmol) of diethyl cyanophosphonate was added dropwise at room temperature, followed by overnight stirring. After the reaction mixture was evaporated under reduced pressure, the resulting crude product was purified by silica gel column chromatography (hexane/ethyl acetate=3/1 to 1/1) to yield the desired product.

후처리

  1. customAfter the reaction mixture was evaporated under reduced pressure
  2. customthe resulting crude product was purified by silica gel column chromatography (hexane/ethyl acetate=3/1 to 1/1)

출처 및 근거

ORD 기록
ord-5b6258c816434dd9bbb6120e933332e1
출처 데이터셋
uspto-grants-1999_12
특허 번호
US05998433

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