Ammonium Chloride → 5-(4-Aminophenyl)-4-chloro-7-isopropylpyrrolo[2,3-d]pyrimidine

HRID 611532노트

반응식

HRID 611532 반응식
[Cl:1][C:2]1[C:3]2[C:10]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=3)=[CH:9][N:8]([CH:20]([CH3:22])[CH3:21])[C:4]=2[N:5]=[CH:6][N:7]=1.[Cl-].[NH4+]>[Fe].O>[NH2:17][C:14]1[CH:15]=[CH:16][C:11]([C:10]2[C:3]3[C:2]([Cl:1])=[N:7][CH:6]=[N:5][C:4]=3[N:8]([CH:20]([CH3:22])[CH3:21])[CH:9]=2)=[CH:12][CH:13]=1

참가 물질

5

반응물 2

HCID 25517Ammonium ChlorideHCID 195974814-Chloro-7-isopropyl-5-(4-nitrophenyl)pyrrolo[2,3-d]pyrimidine

생성물 1

HCID 195974875-(4-Aminophenyl)-4-chloro-7-isopropylpyrrolo[2,3-d]pyrimidine

시약·촉매·용매 2

HCID 23925Iron촉매HCID 962Water용매

실험 절차

A mixture of 4-chloro-7-isopropyl-5-(4-nitrophenyl)pyrrolo[2,3-d]pyrimidine (1.0 g), iron powder (1.76 g), ammonium chloride (86 mg), water (8 ml) and industrial methylated spirit (40 ml) was boiled under reflux for one hour. The mixture was filtered and the solvent evaporated. The residue was taken up in ethyl acetate and washed with water. The ethyl acetate extract was dried, filtered and evaporated to give 5-(4-aminophenyl)-4-chloro-7-isopropylpyrrolo[2,3-d]pyrimidine.

후처리

  1. temperatureunder reflux for one hour
  2. filtrationThe mixture was filtered
  3. customthe solvent evaporated
  4. washwashed with water
  5. extractionThe ethyl acetate extract
  6. customwas dried
  7. filtrationfiltered
  8. customevaporated

출처 및 근거

ORD 기록
ord-4836753ec72e49499603987c56851b6e
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06001839

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