Ethyl bromopyruvate → HCID 178419569, 화합물

HRID 611596

반응식

HRID 611596 반응식
[Br:1][CH2:2][C:3](=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:10]([NH2:16])([NH2:15])=[N:11][C:12]([NH2:14])=[S:13]>C(O)C>[BrH:1].[NH:11]([C:12]1[S:13][CH:2]=[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[N:14]=1)[C:10]([NH2:16])=[NH:15]

참가 물질

4

반응물 2

HCID 66144Ethyl bromopyruvateHCID 2724563Amidinothiourea

생성물 1

HCID 178419569HCID 178419569, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

13.9 ml of ethyl bromopyruvate are added to a solution of 11.81 g of 2-imino-4-thiobiuret (Aldrich) in 100 ml of ethanol and the reaction mixture is heated under reflux for 3 hours (J. Med. Chem. 34, 914-918 (1991)). Subsequently, the mixture is cooled to room temperature and the reaction product is precipitated by the addition of 550 ml of ethyl acetate and filtered off. There are obtained 14.6 g of yellowish ethyl 2-guanidino-thiazole-4-carboxylate hydrobromide. MS: 214 (M)+.

후처리

  1. temperaturethe reaction mixture is heated
  2. temperatureunder reflux for 3 hours (J. Med. Chem. 34, 914-918 (1991))
  3. customthe reaction product is precipitated by the addition of 550 ml of ethyl acetate
  4. filtrationfiltered off

출처 및 근거

ORD 기록
ord-f50c18ad823042108b859b83988eafec
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06001855

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